Developmental Origins and Nephron Endowment in Hypertension
نویسندگان
چکیده
منابع مشابه
Developmental Origins and Nephron Endowment in Hypertension
Primary hypertension continues to be one of the main risk factors for cardiovascular disease worldwide. A stable intrauterine environment is critical for the future development and health of the fetus. The developing kidney has been found to be especially vulnerable during this time period, and epidemiological studies have demonstrated that an adverse in utero environment is associated with an ...
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While low nephron number is associated with increased risk of developing cardiovascular and renal disease, the functional consequences of a high nephron number are unknown. We tested the hypothesis that a high nephron number provides protection against hypertensive and renal insults. Mean arterial pressure (MAP) and renal function were characterized in male wild-type (WT) and transforming growt...
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Uteroplacental insufficiency in the rat restricts fetal growth, impairs mammary development, compromising postnatal growth; and increases adult BP. The roles of prenatal and postnatal nutritional restraint on later BP and nephron endowment in offspring from mothers that underwent bilateral uterine vessel ligation (restricted) on day 18 of pregnancy were examined. Sham surgery (control) and a gr...
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The risk of developing many adult-onset diseases, including hypertension, type 2 diabetes, and renal disease, is increased in low-birth-weight individuals. A potential underlying mechanism contributing to the onset of these diseases is the formation of a low nephron endowment during development. Evidence from the human, as well as many experimental animal models, has shown a strong association ...
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T he concept that environmental factors during development—both in utero and in early childhood—can permanently alter the adult phenotype derives from the seminal epidemiologic observations of Professor David Barker (1). He and his colleagues showed in the early 1990s that low birthweight predicted increased risk of cardiovascular diseases, including insulin resistance/diabetes (2–4), obesity (...
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ژورنال
عنوان ژورنال: Frontiers in Pediatrics
سال: 2017
ISSN: 2296-2360
DOI: 10.3389/fped.2017.00151